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Facebook email logo Email. Description. TNF receptor superfamily member 9 [ Source:HGNC Symbol;Acc:HGNC:11924]. Gene Synonyms. 4-1BB, CD137, ILA.

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qSTAR qPCR primer pairs against Homo sapiens gene TNFRSF9. CD137 (TNFRSF9) Human qPCR Primer Pair (NM_001561) CAT#: HP205417 Reviews Write a review. qSTAR qPCR primer pairs against Homo sapiens gene TNFRSF9. Datasheet. SDS. SensiMix SYBR Master Mix. USD 120.00. Availability*

1, 2 CD137 receptor delivers potent costimulatory signals to activated T lymphocytes maintaining cell division, facilitating differentiation into effector and memory cells and acting as an important survival factor. 3, 4, 5 In addition CD8+ and CD4+ T cells up-regulated CD137 gene expression [9]. Later in 1993, using T-cell leukaemia virus type 1-transformed human T cells, the human homologue of the murine CD137 gene sequence was cloned [1]. In both the murine and the human systems, CD137 is predominantly expressed on CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. Santa Cruz Biotechnology, Inc. offers a broad range of gene silencers in the form of siRNAs, shRNA Plasmids and shRNA Lentiviral Particles.

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Loaded sensors were incubated with 100 nM of each antibody, and binding response was measured. Gene description i. x Evidence i x Tissue i. Cell type i.

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Sensitivity: 0.2 ng/mL DGIdb, The Drug Gene Interaction Database, CD137 CDw137 ILA 602250 11924 ENSG00000049249 OTTHUMG00000001223 1878 Q07011 CD_antigen=CD137 T-cell antigen ILA To test the direct impact of IL‐1α on the CD137 gene expression, we incubated T‐Rex/K‐Ras/off (not incubated with doxycycline) cells with various concentrations of IL‐1α for 24 h. CD137 mRNA levels were increased by IL‐1α in a dose‐dependent manner up to 10 ng/mL, which induced a > 20‐fold increase in CD137 mRNA expression in T‐Rex/K‐Ras/off cells (Fig. 4b ). In addition, the CD137 and CD137L genes can also be evaluated for their potential as biomarkers of SLE. By adopting the next-generation sequencing technique, our centre is currently evaluating the impact of CD137 and CD137L gene polymorphisms on clinical manifestations and treatment responses in our lupus cohort.

Gene and Protein Information; Previous and Unofficial Names; Database Links ILA | CD137 | Ly63 | tumor necrosis factor receptor superfamily, member 9 

Cd137 gene

Mouse CD137 is located at 75.5 cm on mouse chromosome 4, and it exhibits approximately 60% homology with human CD137 [ 9 ]. When CD137 and CD137L genes were cloned and sequenced, they lacked any known intracellular signaling domains; therefore, they ought to rely on adaptors like other members of the TNFR family. Genetic reconstitution of CD137 reversed these defects. CD137 deficiency is a novel inborn error of human immunity characterized by lymphocytic defects with early-onset Epstein-Barr virus (EBV)-associated lymphoma.

Cd137 gene

Our findings elucidate a functional role and relevance of CD137 in human immune homeostasis and antitumor responses. 2018-01-01 TNFRSF9 gene / cDNA is a protein-coding gene which located on 1p36.23. The TNFRSF9 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.168 organisms have orthologs with human gene TNFRSF9.
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Later in 1993, using T-cell leukaemia virus type 1-transformed human T cells, the human homologue of the murine CD137 gene sequence was cloned [1]. In both the murine and the human systems, CD137 is predominantly expressed on 0 users want this gene increased, 0 users want it decreased CD antigen CD137. Top Gene-Substance Interactions. TNFRSF9 Interacts with These Diseases.

Datasheet. SDS. SensiMix SYBR Master Mix. USD 120.00. Availability* Rat Monoclonal CD137 antibody [3H3]. Validated in Activation.
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Cd137 gene




CD_antigen: CD137

This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.

Gene Key is about the Siddhi of Empathy, the Gift of Discernment, and the Shadow of Discord. Deliver Precision Prescribing with GeneDose LIVE · Coriell Life Sciences · More videos · More videos on YouTube. lymphocytes (1). Stimulation of CD137 with agonist antibodies or its natural ligand co- As can be seen in Figure 9A, CD137 gene transfer led to slight NF- κB. The CD137 is a member of the tumor necrosis factor receptor family and a potent regulator of T cell activities.